What causes yellow spots on the palms resembling iodine tincture, and what should be done about it?

Yellowish spots on the palms resembling iodine stains may result from contact with dyeing substances, friction-induced pigmentation, palmar-plantar keratoderma, dyshidrotic eczema (pompholyx), or contact dermatitis. These conditions can be improved through proper cleansing and skincare, avoiding irritants, and medical treatment. If the yellowish spots spread or are accompanied by itching, pain, or peeling, prompt medical attention is recommended.

1. Contact with Dyeing Substances: Contact with pigmented materials such as iodine tincture, dyes, or citrus peels can cause pigment to adhere to the palms, forming yellowish spots without other discomfort. It is recommended to wash the hands thoroughly with soap and water and avoid re-exposure to the staining source. In most cases, the discoloration gradually fades over time.

2. Friction-Induced Pigmentation: Prolonged manual labor or repeated friction can thicken the skin's stratum corneum and lead to pigment deposition, resulting in yellowish spots accompanied by rough skin texture. Reduce local friction, apply moisturizing creams to soften the thickened skin, and avoid frequent exposure to irritating substances.

3. Palmar-Plantar Keratoderma: This condition, caused by genetic factors or vitamin deficiency, leads to excessive thickening of the stratum corneum on the palms and soles, presenting as light yellow patches along with dryness and fissures. Patients may use medications such as salicylic acid ointment, urea ointment, or tretinoin cream under medical supervision to alleviate symptoms.

4. Dyshidrotic Eczema (Pompholyx): Triggered by excessive sweating of the hands and feet or emotional stress, this inflammatory skin condition results in small blisters that, after drying, form light yellow crusts or pigmented spots, often accompanied by itching and peeling. Under a doctor’s guidance, treatments such as calamine lotion, triamcinolone acetonide-urea cream, or loratadine tablets may be used to relieve symptoms.

5. Contact Dermatitis: Exposure to allergens such as detergents or metals triggers skin inflammation, leading to redness, light yellow papules, or areas of hyperpigmentation, usually accompanied by itching. As directed by a physician, topical treatments like desonide cream, mometasone furoate cream, or oral antihistamines such as cetirizine drops can help manage symptoms.

To maintain healthy palms, keep hands clean and dry, avoid contact with irritants and allergens, wear gloves during manual work, regularly apply moisturizer, maintain a balanced diet rich in vitamins, and follow a regular sleep schedule to reduce the risk of skin problems.