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What medicine feels especially cool when applied to the skin?

Nov 29, 2025 Source: Cainiu Health
Dr. Liu Wenmin
Introduction
Medications that feel particularly cooling when applied to the skin include compound menthol ointment, compound camphor cream, calamine lotion, cooling oil, and compound menthol ointment. Compound menthol ointment contains menthol, which, upon application, volatilizes and stimulates the nerve endings in the skin, quickly producing a cooling sensation. It also helps relieve skin itching and mild redness or swelling, making it suitable for conditions such as insect bites or itching caused by dry skin.

Generally, medications that feel particularly cooling when applied to the skin include compound menthol ointment, compound camphor cream, calamine lotion, cooling oil, and compound menthol ointment. The details are as follows:

1. Compound Menthol Ointment: Contains menthol, which produces a rapid cooling sensation by stimulating nerve endings in the skin through evaporation after application. It also helps relieve skin itching and mild redness or swelling, making it suitable for insect bites and itching caused by dry skin.

2. Compound Camphor Cream: Contains camphor, which releases a cooling aroma upon application, providing a refreshing feeling. It helps soothe the skin and alleviate minor pain, useful for relieving discomfort from minor scrapes and insect bites.

3. Calamine Lotion: Although a liquid preparation, it forms a thin film on the skin surface. As the moisture evaporates, it produces a noticeable cooling effect. It has astringent properties and relieves itching, making it ideal for skin irritation caused by prickly heat or eczema.

4. Cooling Oil: Contains multiple cooling ingredients such as menthol and camphor, producing a strong and long-lasting cooling sensation. It can help relieve discomfort from insect bites, mild heatstroke (such as dizziness), and itchy skin. Avoid contact with mucous membranes during use.

5. Compound Menthol Ointment: In addition to menthol, it contains other soothing ingredients, offering a gentle yet lasting cooling effect. It moisturizes the skin and alleviates itching and mild inflammation, making it suitable for daily care of dry skin and after insect bites.

Before using these medications, clean the skin and avoid applying them to broken, ulcerated, or damaged skin areas, as well as near the eyes, nose, mouth, or other mucosal regions. Discontinue use immediately and wash off if stinging, redness, or other irritation occurs. Children and pregnant women should consult healthcare professionals before use to ensure safety.

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