Can vaccines enter the skin through dressings?

Dec 12, 2025 Source: Cainiu Health
Dr. Li Feng
Introduction
Under normal circumstances, vaccines cannot penetrate the skin through conventional dressings. After vaccination, medical dressings should be properly applied to cover the injection site to prevent friction and contamination. Keep the dressing dry and clean; if leakage or loosening occurs, replace it promptly, ensuring hand hygiene before changing the dressing. Avoid contact between the injection site and contaminated water in the short term after vaccination.

Under normal circumstances, vaccines cannot penetrate the skin through traditional dressings. The detailed explanation is as follows:

 

Traditional dressings do not enhance drug permeation, and vaccines require specific administration methods to activate an immune response. Conventional dressings are primarily used to cover wounds and absorb exudate; their material structure cannot overcome the barrier of the skin's stratum corneum, making it difficult for vaccine components to passively enter the subcutaneous tissue. Moreover, vaccines must be directly injected into muscle or under the skin to ensure accurate dosing and effective recognition by the immune system. The application method of traditional dressings cannot meet these delivery requirements, thus they cannot achieve effective vaccine delivery.

After vaccination, medical dressings should be properly applied to the injection site according to guidelines to prevent friction and contamination. Keep the dressing dry and clean, and replace it promptly if leakage or loosening occurs, ensuring hand hygiene before changing. Avoid contact with contaminated water at the injection site shortly after vaccination, and do not apply ointments or skincare products arbitrarily. Monitor the injection site regularly, and seek medical advice promptly if abnormalities such as increased redness, swelling, pain, or fever occur. Follow professional guidance to complete the full vaccination schedule, and never rely on unproven or non-standard administration methods to ensure safe and effective immunization.

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