Can isotretinoin cure oily skin permanently?

Generally, isotretinoin cannot cure oily skin, but it may improve symptoms of oily skin under specific conditions. The detailed analysis is as follows:

Isotretinoin cannot fundamentally cure oily skin. The main reason lies in the fact that oily skin primarily stems from genetic and hormonal factors—innate and internal influences that are difficult to alter completely with medication. This drug can only temporarily reduce sebum production by regulating sebaceous gland function, thereby alleviating symptoms such as oily skin and enlarged pores. However, after discontinuation of the drug, sebaceous gland activity may gradually return to baseline, leading to a rebound in oiliness. Therefore, isotretinoin improves symptoms only during treatment but does not address the root cause.

During treatment, proper skin moisturization is essential, as the medication may cause dryness and flaking. Using gentle moisturizers can help minimize discomfort. For daily cleansing, opt for mild facial cleansers to avoid over-cleansing, which might irritate the skin and trigger compensatory sebum production. In terms of diet, reduce intake of high-sugar and high-fat foods, as these can promote increased sebum secretion. Additionally, maintain a regular sleep schedule and avoid staying up late to minimize hormonal fluctuations that affect skin condition, thus helping to sustain skin stability.