What is hepatitis B mother-to-child transmission?

Dec 01, 2025 Source: Cainiu Health
Dr. Gao Jun
Introduction
Mother-to-child transmission of hepatitis B refers to the transmission of the hepatitis B virus from infected mothers to their fetuses or newborns during pregnancy, childbirth, or close postnatal contact. It is one of the major routes of hepatitis B transmission. If the mother is infected with hepatitis B virus, timely prenatal examinations and interventions are recommended. Transmission mainly occurs in three stages, during which the virus may pass through

Vertical transmission of hepatitis B refers to the transmission of the hepatitis B virus from an infected mother to her fetus or newborn during pregnancy, childbirth, or close contact after delivery. It is one of the major routes of hepatitis B infection. If the mother is infected with hepatitis B virus, timely medical testing and interventions during pregnancy are recommended.

Transmission mainly occurs in three stages: during pregnancy, the virus may cross the placenta and infect the fetus; during delivery, newborns can become infected through exposure to maternal blood and bodily fluids; after birth, transmission may also occur via breastfeeding or close daily contact, although the risk in these postnatal scenarios is relatively low.

The higher the maternal viral load of hepatitis B, the greater the risk of transmission. If the mother is hepatitis B "large three positive" (HBsAg, HBeAg, and anti-HBc positive) or has a high viral load, the probability of transmission without preventive measures is significantly increased. However, appropriate mother-to-child transmission prevention protocols can greatly reduce this risk.

During pregnancy, liver function and viral load should be regularly monitored as directed by a physician. After birth, newborns should promptly receive the hepatitis B vaccine and hepatitis B immunoglobulin. Mothers should maintain good personal hygiene, avoid exposing the newborn to bodily fluids—especially near wounds—and maintain healthy lifestyle habits to strengthen their own health.

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