Hepatic injury caused by anethole trithione

Dec 02, 2025 Source: Cainiu Health

Dr. Gao Jun

Introduction

Anethole trithione causes minimal liver damage when used as directed. In rare cases, it may lead to abnormal liver function. Overdose or improper use can increase the metabolic burden on the liver and may even induce liver injury. If symptoms such as yellowing of the skin, fatigue, or loss of appetite occur during treatment, medical attention is recommended. Anethole trithione is primarily metabolized by the liver, which can normally tolerate its metabolism at standard doses.

When used as directed, anethole trithione has minimal impact on the liver. In rare cases, it may cause abnormal liver function. Overdose or improper use can increase the metabolic burden on the liver and even trigger liver injury. If symptoms such as yellowing of the skin, fatigue, or loss of appetite occur during treatment, medical attention is recommended.

Anethole trithione is primarily metabolized by the liver, which can normally tolerate its metabolic process at standard doses. However, due to individual differences, some people may experience mild elevations in transaminase levels. These typically resolve gradually after discontinuation of the drug and generally do not affect ongoing treatment.

Long-term excessive intake of anethole trithione may exceed the liver's metabolic capacity, leading to drug accumulation in the liver, potentially damaging hepatocytes and causing parenchymal liver lesions. Individuals with pre-existing liver conditions such as chronic hepatitis or cirrhosis have reduced liver metabolism function, making them more susceptible to liver injury when taking this medication.

The drug should be taken strictly according to medical instructions—do not adjust the dose or extend the treatment duration without guidance. Liver function should be monitored regularly during treatment, and concomitant use with other hepatotoxic drugs should be avoided. Maintain a light, easily digestible diet, reduce intake of greasy and spicy foods, and follow a regular daily routine to minimize stress on the liver.

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Can people with liver damage receive the COVID-19 vaccine?

In general, whether patients with liver injury can receive the COVID-19 vaccine depends on the severity of their condition. Those with mild, stable liver injury can usually be vaccinated, whereas individuals with moderate to severe or acute-phase liver injury are not advised to get vaccinated immediately. Patients with liver injury should strictly follow medical advice regarding medication and avoid taking drugs that are hepatotoxic. They should maintain a light and balanced diet, reducing intake of greasy foods.

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Can I take Compound Paracetamol and Dextromethorphan Syrup when my temperature is 38°C?

If the body temperature is 38°C without any cold symptoms, or if the fever is caused by other conditions such as bacterial infection (e.g., pneumonia) or autoimmune diseases, or if the patient has severe underlying diseases such as liver or kidney dysfunction or glaucoma, this medication is not recommended. Taking the drug in these situations will not address the underlying cause, may mask the true condition with its active ingredients, delay diagnosis, or exacerbate the burden on pre-existing medical conditions.