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What is the difference between recombinant human interferon and human interferon?

Dec 02, 2025 Source: Cainiu Health
Dr. Gao Jun
Introduction
The differences between recombinant human interferon and human interferon include different sources, varying purity levels, differing efficacy stability, distinct side effect profiles, and different manufacturing processes. The two have slightly different clinical applications and should be selected according to medical advice based on the specific condition. If severe fever, allergic reactions, or abnormal liver and kidney function occur after medication, prompt medical attention is recommended.

　　The differences between recombinant human interferon and human interferon include different sources, purity levels, therapeutic stability, side effect profiles, and manufacturing processes. Their clinical applications vary slightly, so selection should be based on medical advice according to individual conditions. If severe fever, allergic reactions, or abnormal liver or kidney function occur after use, prompt medical attention is recommended.

　　1. Different sources: Human interferon is extracted from human blood or tissues and contains a mixture of natural interferon subtypes; recombinant human interferon is produced through genetic engineering techniques using microorganisms, offering more controllable sourcing and easier large-scale production.

　　2. Different purity: During extraction, human interferon is prone to contamination with other protein impurities, resulting in lower purity; recombinant human interferon allows precise expression of a single subtype, with extremely low impurity content, higher purity, and better clinical safety.

　　3. Different therapeutic stability: The activity and efficacy of human interferon can vary significantly due to individual differences in raw materials; recombinant human interferon is manufactured under standardized processes, ensuring stable biological activity, predictable efficacy, and consistent treatment outcomes.

　　4. Different side effect profiles: Due to the presence of impurities, human interferon may cause more pronounced systemic reactions such as fever and fatigue in some individuals; recombinant human interferon generally causes milder side effects with lower incidence rates and better tolerability.

　　5. Different manufacturing processes: Human interferon relies on traditional extraction and separation techniques, which limits yield and increases cost; recombinant human interferon uses gene cloning and fermentation technologies, enabling high production efficiency, controllable costs, and better ability to meet clinical demands.

　　Medication should be used strictly according to prescribed dosage and duration; do not adjust the treatment regimen without guidance. Storage must follow product instructions, typically requiring refrigeration to prevent loss of biological activity. Maintain regular作息 (daily routines), avoid fatigue, and follow a light, balanced diet during treatment to support the body's tolerance to the medication.

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