What are the side effects of lenvatinib?
Dec 03, 2025
Source: Cainiu Health
Dr. Li Feng
Introduction
The common formulation of lenvatinib is capsule. Generally, the main side effects of lenvatinib include hypertension, diarrhea, hand-foot skin reaction, fatigue, decreased appetite, etc. During treatment with lenvatinib, it is essential to strictly follow medical instructions for medication and not adjust the dosage or discontinue the drug without guidance. Regular hospital visits for relevant examinations are required, and any discomfort or adverse symptoms should be promptly reported to healthcare providers.
Lenvatinib is commonly available in capsule form. Generally, the main side effects of lenvatinib include hypertension, diarrhea, hand-foot skin reaction, fatigue, and decreased appetite. A detailed analysis is as follows:
1. Hypertension
The drug may affect vascular constriction function, leading to elevated blood pressure. Some patients may experience accompanying symptoms such as dizziness or headache. Blood pressure should be monitored regularly during treatment. Any abnormal readings should be promptly reported to a physician. Antihypertensive medications may be required as directed by a doctor when necessary. Additionally, maintaining a low-salt diet can help stabilize blood pressure.
2. Diarrhea
The medication may irritate the intestinal mucosa and accelerate intestinal motility, potentially causing diarrhea, with severity varying among individuals. Mild diarrhea can be relieved through dietary adjustments—avoiding spicy, raw, cold, and greasy foods, while consuming more warm, easily digestible meals. In cases of significant diarrhea, prompt medical attention is needed. Anti-diarrheal medications should be used according to medical advice to prevent dehydration.
3. Hand-Foot Skin Reaction
Redness, swelling, and pain may occur on the palms and soles; severe cases may involve peeling or cracking of the skin. Proper care of hands and feet is essential during daily activities—avoid friction and pressure, wear loose, soft footwear and socks, and apply mild moisturizers to maintain skin hydration. If symptoms become severe, medication should be temporarily discontinued and targeted treatment initiated under medical guidance.
4. Fatigue
Patients often feel general tiredness and low energy, with noticeably reduced exercise tolerance. When fatigue occurs, adequate rest should be ensured and overexertion avoided. Daily routines should be reasonably scheduled. Light physical activities such as walking may be beneficial. Consuming foods rich in protein and vitamins can aid in restoring strength.
5. Decreased Appetite
The drug may alter taste perception or irritate the gastrointestinal tract, resulting in reduced appetite. Prolonged loss of appetite may lead to weight loss. Dietary strategies include preparing varied, lightly flavored meals and eating smaller portions more frequently. If necessary, consult a nutritionist to develop an appropriate meal plan that ensures sufficient nutritional intake and prevents malnutrition.
During treatment with lenvatinib, it is essential to strictly follow the prescribed regimen—do not adjust the dose or discontinue the medication without medical instruction. Regular hospital visits for follow-up examinations are required, and any discomfort should be promptly reported to healthcare providers. Maintaining healthy lifestyle habits—including regular sleep patterns and a balanced diet—can help reduce the impact of side effects and improve medication safety.
