What is double Y chromosome?
Disease description:
Recently, I've noticed that my speech has become slower. The doctor said it's caused by a double Y chromosome. What exactly is a double Y chromosome?
Doctor's answer (1)
Dr. Wang Xueying
The genetic cause of double Y chromosome syndrome is generally due to nondisjunction of the Y chromosome during the second meiotic division of sperm. The etiology of double Y chromosome syndrome involves rare mosaic variants, with approximately two-thirds being 47,XYY and the remainder 48,XXYY. In most patients, during spermatogenesis, the extra Y chromosome is eliminated prior to germ cell formation through non-selective segregation, resulting in offspring that are usually normal, although a minority may be 47,XYY. For patients wishing to have children, it is recommended to achieve pregnancy through in vitro fertilization or other assisted reproductive technologies.
