What are the pathogenic mechanisms of rheumatoid arthritis?
Disease description:
The pathogenesis of rheumatoid arthritis generally involves antigens entering the body and being first phagocytized by antigen-presenting cells such as macrophages. After processing and concentration, these antigens combine with molecules on the surface of phagocytic cells to form complexes. Once recognized by T-cell receptors, a three-molecule complex is formed. Through the secretion of various cytokines and mediators, inflammation and joint destruction occur. Meanwhile, activated B lymphocytes differentiate into plasma cells, secreting large amounts of immunoglobulins including rheumatoid factor and other antibodies. These form antigen-antibody immune complexes that further promote inflammatory responses.
Doctor's answer (1)
Dr. Liu Aihua
Recently diagnosed with rheumatoid arthritis, but unclear about the causes. Would like to know the pathogenesis of rheumatoid arthritis.
