How to treat acanthosis nigricans in obesity?

Acanthosis nigricans associated with obesity should be treated primarily by weight loss, along with the use of topical retinoids. As body weight decreases, the condition will gradually improve. The mainstay of treatment is weight reduction and addressing the underlying cause. For example, patients with obesity-related pseudo-acanthosis nigricans can control their diet, increase physical activity, and lose weight to promote recovery. Regular application of vitamin-containing creams can help reduce pigmentation and skin lesions, and local cryotherapy may also be considered.