Does acanthosis nigricans cause itching?

Jun 09, 2025 Source: Cainiu Health
Disease description:

My neck and underarm skin has recently become dark and rough, feeling slightly thickened. These areas are usually not very itchy, but occasionally cause a mild prickling sensation when I sweat more than usual. Could this be acanthosis nigricans?

Doctor's answer (1)
Dr. Liu Wenmin

Whether acanthosis nigricans causes itching depends on individual differences and the severity of the condition.

The main features of acanthosis nigricans include darkening and thickening of the skin, along with the development of numerous skin tags, which may appear as papillary projections or wart-like elevations and feel soft in texture. During disease progression, the skin may become rough, thickened, and the skin lines may widen and deepen. These skin changes themselves do not directly cause itching.

However, in some cases, excessive keratinization and a moist environment may increase the risk of bacterial or fungal infections, which could then cause itching. Additionally, due to skin thickening and increased skin folds, local friction might also cause discomfort or mild itching. If itching is significant, mild anti-inflammatory and antipruritic medications or topical ointments, such as corticosteroid-containing creams, may be used under a physician's guidance to alleviate symptoms.

In daily life, it is recommended to keep the skin clean and avoid excessive friction and squeezing, which can also help reduce itching.