Can a child with normal liver function and positive "big three" hepatitis B markers achieve seroclearance?
Disease description:
The child's liver function tests were normal, but he/she tested positive for the "big three" (HBsAg, HBeAg, and anti-HBc). I'm not sure whether it can turn negative. Can the "big three" become negative when liver function is normal?
Doctor's answer (1)
Dr. Zhou Xiaofeng
There is a possibility, though relatively low, for children with normal liver function but positive for the "big three" hepatitis B markers (HBsAg, HBeAg, and anti-HBc) to achieve seroclearance. 1. The "big three" pattern is usually caused by mother-to-child transmission. In the early stage of infection, children lack sufficient immune capacity, which may lead to a stable state between the hepatitis B virus and the body, making it difficult for the immune system to completely eliminate the virus. 2. Even with normal liver function, the likelihood of seroclearance is influenced by multiple factors, including the level of viral replication, individual differences, and treatment approaches. 3. For pediatric patients with the "big three" pattern, regular monitoring of hepatitis B virus DNA, transaminase levels, and other indicators is recommended. Appropriate management strategies, such as liver-protective and antiviral medications, should be implemented according to medical advice to increase the chances of seroclearance.
