Is the squamous cell carcinoma antigen (SCC) test accurate?

Jun 14, 2024 Source: Cainiu Health
Disease description:

Recently, I suspected that I might have cervical cancer and had a test for squamous cell carcinoma antigen. May I ask, is the squamous cell carcinoma antigen (SCC) test accurate?

Doctor's answer (1)
Dr. Yang Ziqi
The squamous cell carcinoma antigen (SCC) test has a certain degree of accuracy in diagnosing squamous cell carcinoma, but the following points should be noted: High specificity: SCC exhibits high specificity for squamous cell carcinoma, particularly in cervical squamous cell carcinoma, where plasma SCC levels are elevated in more than 70% of patients, making it an important auxiliary tool in diagnosis. Auxiliary diagnosis: Although the SCC test aids in diagnosing squamous cell carcinoma, it is not the gold standard. Confirmation of malignancies such as cervical cancer still requires more accurate diagnostic methods, including pathological examination. Monitoring treatment response: SCC levels can also serve as an indicator for monitoring treatment efficacy. For example, in cervical cancer patients, a持续 decline in SCC levels after treatment generally indicates a favorable therapeutic response. Potential for false positives: False-positive results may occur due to various factors, such as poor blood collection technique or contamination by sweat or saliva. In summary, the squamous cell carcinoma antigen (SCC) test demonstrates certain accuracy in the diagnosis and assessment of treatment outcomes for squamous cell carcinoma, but comprehensive evaluation should include integration with other diagnostic methods.