
Is rickets hereditary?
Disease description:
My legs are bowed (O-shaped legs), which is due to rickets. I am worried about passing it on to my children. Is rickets hereditary?

Whether rickets is hereditary depends on the specific situation:
1. Non-hereditary rickets: In general, rickets is not a hereditary disease. Its primary cause is vitamin D deficiency, which leads to disturbances in calcium and phosphorus metabolism and impaired calcification of osteoid tissue. This type of rickets is mainly caused by insufficient exposure to sunlight, improper feeding, rapid growth, chronic diseases, or medication effects, and it does not have hereditary characteristics.
2. Vitamin D-resistant rickets: This is a special type of hereditary rickets, classified as a renal tubular genetic disorder associated with hereditary defects in the renal tubules. It is primarily inherited as an X-linked dominant trait, following a specific pattern of inheritance. If the mother is a carrier of the disease gene and the father is unaffected, there is a 50% chance of having an affected daughter and a 50% chance of having an affected son.