What does elevated direct bilirubin mean?

Elevated direct bilirubin indicates that the level of direct bilirubin in the serum is higher than the normal range. This usually suggests an impairment in the excretion of direct bilirubin through the biliary tract after liver cell damage, or obstruction preventing bile from entering the intestinal cavity normally, leading to jaundice. Possible causes include strenuous exercise, acute cholangitis, and hepatobiliary calculi. Physiological factors such as intense physical activity and excessive fatigue typically cause temporary increases in direct bilirubin, which generally resolve spontaneously. Pathological factors, such as hepatitis and cirrhosis, may lead to persistently elevated direct bilirubin levels and require timely medical evaluation and treatment. Patients with elevated direct bilirubin should follow medical advice for interventions, which may include medication, surgery, or lifestyle modifications.