Can the "Big Three Yang" (major hepatitis B markers) be completely cured?
Disease description:
Last year, I was diagnosed with being "big three positive" (a term referring to certain positive markers for hepatitis B), and I have been actively undergoing treatment. Can the "big three positive" status be completely cured?
Doctor's answer (1)
Dr. Yang Ziqi
"Big Three Yang," or "Big Three Positive" in hepatitis B, refers to a positive result for three items in the hepatitis B five-panel test: hepatitis B surface antigen (HBsAg), e antigen (HBeAg), and core antibody (anti-HBc). This typically indicates the presence of hepatitis B virus (HBV) in the body and active viral replication. Currently, "Big Three Yang" cannot be cured completely, primarily because the replication template of HBV, covalently closed circular DNA (cccDNA), resides deep within the cell nucleus and is difficult to effectively eliminate. Existing treatment approaches mainly use antiviral medications to suppress viral replication and control disease progression, but these treatments cannot fully eradicate the virus. Statistics show that only about 3%-5% of patients achieve clearance of HBsAg through treatment, which is considered a clinical cure. Therefore, treatment for "Big Three Yang" requires long-term and standardized management, and patients need to maintain a positive attitude and cooperate closely with their physicians regarding treatment and follow-up examinations.
