Can the use of antihypertensive drugs cause edema?

The use of antihypertensive medications may potentially cause edema, especially certain specific types of these drugs. Among them, calcium channel blockers (also known as calcium antagonists) are among the most common antihypertensive drugs that cause edema. These medications, such as nifedipine and felodipine, dilate small arteries and precapillary sphincters, leading to increased hydrostatic pressure in capillaries, which can result in edema. This condition typically manifests as swelling in the lower limbs or facial area, although it can also occur in other parts of the body. Besides calcium channel blockers, other types of antihypertensive drugs such as diuretics, beta-blockers, ACE inhibitors (commonly known as "Prils"), and ARBs (often referred to as "Sartans") may also cause various side effects; however, they are relatively less likely to induce edema. Due to individual differences in physical conditions and disease status, people may respond differently to medications. Therefore, when using antihypertensive drugs, it is important to closely monitor bodily reactions and make appropriate medication choices and adjustments under a physician's guidance.