What are the long-term effects of taking sustained-release nifedipine tablets?

Long-term use of nifedipine sustained-release tablets may lead to a series of effects, including but not limited to the following aspects: 1. Hypotension: Nifedipine sustained-release tablets dilate blood vessels to lower blood pressure. Excessive dilation may lead to abnormally low blood pressure, causing symptoms such as dizziness, weakness, and fainting. 2. Bradycardia: Long-term excessive use of this medication may cause bradycardia, manifested as chest tightness, dizziness, fatigue, and other symptoms. 3. Headache: Nifedipine sustained-release tablets dilate cerebral blood vessels to improve cerebral blood supply; however, excessive dilation may trigger headaches. 4. Edema: The medication may increase capillary permeability, causing fluid to leak from blood vessels into surrounding tissues, resulting in edema, particularly in the lower limbs or face. 5. Liver damage: Long-term use of nifedipine sustained-release tablets may cause liver damage, manifested as abnormal liver function or even liver failure. Therefore, regular monitoring of liver function is recommended. 6. Other side effects: These may include facial flushing, gastrointestinal discomfort (e.g., nausea, stomach pain, diarrhea), loss of appetite, allergic reactions (e.g., rash, urticaria), and others. If any discomfort occurs, patients should promptly consult a physician and adjust the treatment regimen.