Is having a small three positive (HBsAg, HBeAb, HBcAb) serious?

Jul 09, 2024 Source: Cainiu Health
Disease description:

I have liver disease and have recently been diagnosed with "small three positives." I would like to ask, is having small three positives serious?

Doctor's answer (1)
Dr. Yang Ziqi
"Minor Three Positive" refers to a blood test result in individuals infected with the hepatitis B virus, showing positivity for the surface antigen, core antibody, and e antibody. This usually indicates the virus is in a low replication state, representing a relatively "carrier" status. The severity of Minor Three Positive varies among individuals. Some patients may remain asymptomatic for a long time with normal liver function and minimal impact from the virus. However, others may have abnormal liver function or be at risk of liver damage, requiring regular monitoring of liver function and viral load. Patients with Minor Three Positive may still progress to chronic hepatitis, cirrhosis, or even liver cancer, so it should not be taken lightly. Regular follow-up with a physician for liver function tests and hepatitis B virus-related indicators is very important, along with antiviral treatment when necessary. In addition, maintaining a healthy lifestyle—such as quitting smoking, limiting alcohol consumption, eating a balanced diet, and engaging in appropriate exercise—can help maintain liver health and reduce the risk of disease progression.