What does it mean when transpeptidase levels are high?

Jul 13, 2024 Source: Cainiu Health
Disease description:

When I had my physical checkup this week, they told me that my transpeptidase level was high. I became very curious about what causes elevated transpeptidase.

Doctor's answer (1)
Dr. Yang Ziqi

Elevated levels of transpeptidase may indicate abnormal liver function. These enzymes are primarily found in liver cells, and when the liver cells are damaged or inflamed, the enzymes are released into the bloodstream, causing elevated results in blood tests. The following are common causes of increased transpeptidase levels:

1. Hepatitis: Viral hepatitis (such as hepatitis A, B, C, etc.) or other types of hepatitis can cause inflammation of liver cells, thereby increasing transpeptidase levels.

2. Fatty liver: Non-alcoholic fatty liver disease or alcoholic liver disease caused by excessive alcohol consumption can both lead to elevated transpeptidase levels.

3. Cirrhosis: When long-term liver disease progresses to cirrhosis, transpeptidase levels typically rise.

4. Liver cancer: Malignant conditions such as liver tumors or intrahepatic bile duct cancer may also affect transpeptidase levels.

If you have any concerns, it is recommended to seek medical attention promptly.