What does "Big Three Positive" for hepatitis B mean?

HBsAg positive, HBeAg positive, and anti-HBc positive, known as the "big three positives" of hepatitis B, refer to a condition in which chronic hepatitis B patients or hepatitis B virus carriers test positive for three hepatitis B immunological markers: hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), and hepatitis B core antibody (anti-HBc). This indicates active replication of the hepatitis B virus in the body and a higher level of infectivity. However, it does not directly reflect the severity of the disease, which requires further evaluation based on liver function status and viral load.

For patients with the big three positives, doctors usually recommend regular monitoring of liver function to assess disease progression and consider antiviral therapy according to individual circumstances. In addition, maintaining healthy lifestyle habits, such as avoiding alcohol consumption, maintaining a balanced diet, getting adequate rest, and avoiding excessive fatigue, can help slow disease progression. Individuals with a history of vaccination or those who have not been infected should receive the hepatitis B vaccine in a timely manner to obtain protection.