Side Effects of Glucocorticoids

The main side effects of glucocorticoids include: 1. Metabolic disturbances: Such as central obesity, moon face, buffalo hump, hypertension, hyperlipidemia, and hyperglycemia. Long-term use may even induce steroid-induced diabetes and osteoporosis. 2. Increased risk of infection: Glucocorticoids reduce the body's defense capabilities, potentially triggering or exacerbating infections caused by bacteria, fungi, or viruses. 3. Gastrointestinal problems: May induce or worsen gastric and duodenal ulcers, which can lead to gastrointestinal bleeding or perforation in severe cases. 4. Other side effects: Include skin atrophy, capillary dilation, pigmentation, cataracts, glaucoma, muscle weakness, and muscle atrophy. The severity and frequency of these side effects vary among individuals. It is recommended to use glucocorticoids under medical supervision to minimize the occurrence of adverse effects.