Can allopurinol and febuxostat be used together?

Allopurinol and febuxostat are generally not recommended for concomitant use. Both medications inhibit uric acid synthesis through similar mechanisms, and combination therapy may increase the risk of adverse drug reactions, with overlapping side effects. Adverse effects of allopurinol include rash, diarrhea, and, in severe cases, exfoliative dermatitis, liver dysfunction, and kidney dysfunction. Common adverse effects of febuxostat include diarrhea and nausea, while severe reactions may involve toxic epidermal necrolysis and abnormal liver function. When using these medications, it is important to follow medical advice and select the appropriate drug based on the patient's individual condition. Regular monitoring of liver and kidney function is necessary to ensure safe medication use. Additionally, patients with high uric acid levels should also pay attention to modifying lifestyle and dietary habits to better manage their condition.