What medications can be taken with febuxostat?

Febuxostat usually refers to febuxostat tablets, which are primarily used to treat hyperuricemia in patients with gout. When taking febuxostat tablets, the following medications may be used under medical supervision to enhance therapeutic effects or alleviate adverse reactions: 1. Colchicine: When fluctuations in uric acid levels may induce an acute gout attack, colchicine can be used in combination. It is primarily used for treating acute gouty arthritis and preventing acute relapses. 2. Nonsteroidal anti-inflammatory drugs (NSAIDs): Such as ibuprofen sustained-release capsules and acetaminophen drops. These medications inhibit prostaglandin synthesis and have anti-inflammatory, antipyretic, and analgesic effects, which can relieve joint pain caused by fluctuations in uric acid levels. 3. Sodium bicarbonate tablets: This is an acid-base balance regulator that helps regulate the body's acid-base balance and alkalinize urine. When taken with febuxostat tablets, it can more effectively reduce uric acid concentration.