Symptoms of Tramadol Overdose

Jul 25, 2024 Source: Cainiu Health
Disease description:

Toothache is really tormenting; every time it flares up, I take large amounts of painkillers to relieve it. I heard from others that long-term use can be harmful. May I ask, what are the manifestations of taking Tramadol in large quantities?

Doctor's answer (1)
Dr. Huang Shichang
Tramadol is a centrally acting analgesic primarily used to relieve moderate to severe pain. However, if taken in large quantities, the following symptoms may occur: 1. Central nervous system (CNS) depression: Convulsions, tremors, hallucinations, anxiety, or restlessness may occur. This is because tramadol exerts an inhibitory effect on the CNS, which is enhanced with overdose. 2. Gastrointestinal problems: Nausea, vomiting, loss of appetite, and constipation may occur due to the drug's effects on gastrointestinal function in cases of overdose. 3. Respiratory complications: Respiratory depression, or even respiratory arrest, may occur, possibly accompanied by rapid breathing, chest tightness, or difficulty breathing. 4. Cardiovascular issues: Hypotension, bradycardia, or arrhythmia may occur, affecting the normal function of the cardiovascular system. 5. Other neurological symptoms: Seizures may be induced, particularly generalized tonic-clonic seizures. 6. Addiction and dependence: Following long-term or high-dose use, patients may develop dependence on tramadol. Upon discontinuation, withdrawal symptoms such as agitation, anxiety, and irritability may appear.