Is 6542 contraindicated in acute pancreatitis?
Disease description:
Hospitalized due to acute pancreatitis, would like to use medication for pain relief. May I ask, is 654-2 contraindicated in acute pancreatitis?
Doctor's answer (1)
Dr. Shen Yonghua
654-2, also known as anisodamine, is an M-cholinergic receptor antagonist commonly used to relieve smooth muscle spasms, improve microcirculation, and more. The use of anisodamine in patients with acute pancreatitis should be undertaken with caution.
The treatment principle for acute pancreatitis is to reduce pancreatic secretion and inflammatory responses. Anisodamine may affect pancreatic secretory function by inhibiting cholinergic nerve activity, which theoretically could reduce the burden on the pancreas. However, in cases of acute pancreatitis, the use of such drugs may increase the risk of paralytic intestinal obstruction.
In the absence of clear indications, anisodamine should not be routinely used. For pain management in acute pancreatitis, drugs such as phloroglucinol and forte pain relief (strong analgesic) can be considered. During treatment, in addition to pain relief, it is also important to maintain water-electrolyte and acid-base balance and reduce pancreatic secretion.
It is recommended to visit a regular hospital and undergo treatment under the guidance of a qualified physician.
