
The earliest symptoms appearing in patients with uremia
Recently, I have been feeling fatigued and weak for unknown reasons, and sometimes my head feels dizzy. After an examination, I was told I have uremia. Could you please explain what symptoms are commonly seen in the early stages of uremia?

Uremia is not an independent disease, but rather a clinical syndrome shared by various late-stage kidney diseases. The following are some common symptoms:
1. Fatigue and weakness: Patients often experience a decline in physical strength and are prone to fatigue, which is caused by the accumulation of metabolic waste in the body affecting energy metabolism.
2. Loss of appetite: In the early stage of uremia, patients may experience reduced appetite, decreased interest in food, and even symptoms such as nausea and vomiting.
3. Increased nocturnal urination: The kidneys are unable to effectively concentrate urine at night, leading to an increased frequency of nighttime urination, which may indicate early kidney damage.
4. Hypertension: The kidneys are responsible for excreting sodium and water. When kidney function is impaired, sodium and water retention occur in the body. Additionally, the kidneys secrete substances that elevate blood pressure, leading to the development of hypertension.
5. Anemia: The kidneys are the primary organ responsible for producing erythropoietin. Impaired kidney function leads to reduced erythropoietin production, causing anemia, which manifests as pallor, dizziness, and other symptoms.