Causes of Elevated Alanine Aminotransferase (ALT)
Disease description:
During a physical examination, I found that my alanine aminotransferase (ALT) level was elevated. What does this mean? I don't usually experience any physical discomfort. I would like to know what might cause this indicator to increase.
Doctor's answer (1)
Dr. Gao Jun
Elevated alanine aminotransferase (ALT) levels may result from either physiological factors or pathological causes.
Alanine aminotransferase, also known as glutamic-pyruvic transaminase, is an enzyme found in the liver. When liver cells are damaged, this enzyme is released into the bloodstream, causing elevated blood levels. Physiological factors such as long-term heavy alcohol consumption, excessive exercise, overeating, and staying up late may lead to abnormal increases in this indicator. Medications also play a significant role, as certain health supplements, tonics, and drugs may cause liver damage, resulting in elevated ALT levels.
In addition, viral hepatitis, such as hepatitis B or C infection, is one of the most common causes. Factors such as obesity, diabetes, and high cholesterol can lead to non-alcoholic fatty liver disease, which may cause elevated alanine aminotransferase levels. Patients with autoimmune liver disease experience damage to liver cells when their immune system mistakenly attacks the liver.
It is recommended to make a comprehensive assessment based on clinical symptoms and other test results. Further tests may be necessary to determine the exact cause, and treatment should be conducted under a doctor's guidance.
