What medications can be taken for overactive immunity?

Feb 27, 2025 Source: Cainiu Health
Disease description:

Recently, I noticed that my immune system is overactive. Could you please advise what medications would be suitable?

Doctor's answer (1)
Dr. Bai Hongmei

Immune hyperactivity usually refers to an overactive immune system, leading to autoimmune diseases or allergic reactions. Diagnosis and treatment must be based on the specific condition, and self-medication is not recommended. Commonly used medications generally fall into the following categories:

1. Glucocorticoids: Such as methylprednisolone, are suitable for immune hyperactivity caused by autoimmune diseases. These drugs have strong anti-inflammatory effects and can inhibit cell-mediated immune responses. Long-term use requires monitoring of blood pressure, blood glucose, and electrolyte levels.

2. Alkylating agents: Such as cyclophosphamide, can be used to treat tumors and autoimmune diseases. They are usually administered intravenously, and monitoring of hematologic parameters and infection prevention are necessary.

3. Calcineurin inhibitors: Such as cyclosporine and tacrolimus, are primarily used to reduce rejection reactions after organ transplantation. Renal function and blood pressure should be closely monitored during treatment.

4. Purine synthesis inhibitors: Such as azathioprine, are indicated for rheumatic diseases and adjuvant treatment of solid tumors. They are contraindicated in patients with impaired bone marrow hematopoietic function, pregnant women, and nursing mothers.

However, drug selection and use must be guided by a physician, as these medications may have serious side effects and require dosage and treatment duration adjustments according to individual patient conditions. Additionally, maintaining a healthy lifestyle—including a balanced diet, moderate exercise, sufficient sleep, and stress reduction—can also help regulate immune system function. If you suspect you have immune hyperactivity, seek medical attention promptly.