Will C-reactive protein be elevated in gout?
Disease description:
Gout attacks frequently, causing swollen and painful joints. During my recent physical examination, I found that my C-reactive protein (CRP) level was elevated. Is this related to gout? Can gout cause an increase in C-reactive protein?
Doctor's answer (1)
Dr. Yang Tiesheng
In general, C-reactive protein (CRP) levels may increase during gout attacks.
CRP is an acute-phase reactant protein whose plasma concentration rises sharply when the body experiences infection or tissue damage. It can activate the complement system and enhance phagocytosis by phagocytes, thereby eliminating invading pathogens as well as damaged, necrotic, and apoptotic tissue cells. CRP serves as a nonspecific biomarker of inflammation.
During acute gout attacks, urate crystal deposition irritates the synovium and joint capsule, triggering local inflammation and activating immune cells such as neutrophils and macrophages. These cells release inflammatory mediators, including interleukin-1β and tumor necrosis factor α. These inflammatory mediators not only contribute to the development of gouty arthritis but also stimulate the liver to produce more CRP, leading to a significant increase in serum CRP levels.
Gout patients are advised to avoid high-purine foods such as seafood, organ meats, and concentrated meat broths in daily life. They should consume more vegetables and fruits, drink plenty of water, and promote uric acid excretion.
