Loss of appetite, constipation, insomnia: What medications can be used for treatment?

May 20, 2025 Source: Cainiu Health
Disease description:

I have recently been experiencing loss of appetite, constipation, insomnia, and overall fatigue. I have tried adjusting my diet, but there has been no improvement. I would like to ask if there are any suitable medications available to help regulate these symptoms?

Doctor's answer (1)
Dr. Shen Yonghua

Loss of appetite may be treated with prokinetic agents such as domperidone, which enhances gastrointestinal motility and helps improve appetite loss caused by indigestion. In addition, supplementation with B-complex vitamins may also help improve appetite.

For constipation, over-the-counter medications such as polyethylene glycol 4000 powder and lactulose oral solution can stimulate intestinal secretion and promote bowel movements. Intestinal motility can also be enhanced with medications such as mosapride citrate capsules, itopride hydrochloride tablets, and domperidone tablets, which help relieve constipation.

For insomnia, over-the-counter options such as melatonin may help regulate the sleep cycle and improve sleep quality. For severe insomnia, doctors may consider prescribing benzodiazepines (e.g., estazolam) or other sleeping pills, although these medications carry a risk of addiction and should be used for short-term only.

All medications should be used under the supervision of a physician to ensure safety and effectiveness. Comprehensive lifestyle modifications, such as regular exercise, maintaining healthy eating habits, and practicing good sleep hygiene, can also help alleviate the above symptoms.