What is the best treatment for lupus erythematosus?

The treatment goals for systemic lupus erythematosus (SLE) are to control disease activity, reduce inflammation, prevent organ damage, and improve quality of life. Currently, there is no cure, but symptoms can be effectively managed through comprehensive treatment approaches.

1. Medication therapy: Nonsteroidal anti-inflammatory drugs (NSAIDs) and antimalarial drugs are used to relieve symptoms such as fever, joint pain, and muscle pain. Glucocorticoids are the primary medications for treating lupus, especially indicated for acute or fulminant cases and when major organs are involved. Immunosuppressants such as cyclosporine A and methotrexate are mainly used in cases of disease recurrence after reducing steroid dosage or when high-dose steroids cause severe side effects.

2. Biologic agents: These medications, such as belimumab and atacicept, target specific molecules or receptors to modulate immune system function.

3. Monitoring and adjusting treatment plans: Regular follow-ups are necessary to monitor indicators such as complete blood count, urinalysis, liver and kidney function, and complement levels, with treatment plans adjusted according to disease activity.

4. Psychological support: Patients often experience emotional issues such as anxiety and depression, so psychological support and interventions are needed.

5. Lifestyle modifications: Avoid direct exposure to ultraviolet light by using sunscreen and wearing protective clothing. Maintain a healthy diet, exercise moderately, avoid excessive fatigue, and maintain a positive mindset.