Can women with polycystic ovary syndrome ovulate when taking dydrogesterone tablets?
Women who take progesterone tablets may still experience ovulation. Dydrogesterone tablets are a commonly used oral progesterone in clinical practice, prescribed for conditions such as polycystic ovarian syndrome and premature ovarian failure caused by insufficient endogenous progesterone secretion.
If a woman taking progesterone tablets experiences ovarian dysfunction and anovulation, it may be due to other underlying conditions such as polycystic ovarian syndrome. It could also be a sign of premature ovarian failure or result from excessive psychological stress during treatment.
The progesterone used in treating polycystic ovarian syndrome primarily compensates for deficient endogenous progesterone. Specifically, dydrogesterone is administered to supplement the lack of endogenous progestin. In polycystic ovarian syndrome, the endometrium is often exposed long-term to unopposed estrogen without the counterbalancing effect of progesterone, which can lead to irregular vaginal bleeding or amenorrhea. Taking dydrogesterone helps regulate the menstrual cycle. For polycystic ovarian syndrome, dydrogesterone should be taken during the second half of the menstrual cycle, and combining it with low-dose estrogen often yields better results.