What does high 25-hydroxyvitamin D mean?
Oct 13, 2022
Source: Cainiu Health
Dr. Wang Lei
Introduction
High levels of 25-hydroxyvitamin D result from excessive intake of vitamin D, leading to its accumulation in the body. Vitamin D is a fat-soluble vitamin, and 25-hydroxyvitamin D is formed when vitamin D undergoes hydroxylation in the liver. Elevated 25-hydroxyvitamin D levels may indicate excessive vitamin D supplementation, resulting in its buildup and causing vitamin D toxicity.
Generally, elevated levels of 25-hydroxyvitamin D may result from excessive vitamin D intake, leading to its accumulation in the body.
Vitamin D is a fat-soluble vitamin whose primary function is to promote the absorption of calcium and phosphorus by cells. 25-Hydroxyvitamin D, a fat-soluble form of vitamin D, is produced in the liver through hydroxylation and represents the main circulating form of vitamin D in the body. High levels of 25-hydroxyvitamin D may indicate excessive vitamin D supplementation, resulting in vitamin D accumulation and potentially causing hypervitaminosis D.
When 25-hydroxyvitamin D levels are mildly elevated, it's important to maintain a balanced diet and minimize additional vitamin D intake. Significantly elevated levels may indicate vitamin D toxicity; in such cases, supplementation with vitamin D or calcium should be discontinued, and foods rich in vitamin D and calcium should be avoided or consumed sparingly to reduce further absorption. If a patient’s 25-hydroxyvitamin D levels remain persistently high and symptoms such as dizziness or nausea develop, immediate medical attention is necessary. Under medical supervision, medications such as prednisone acetate tablets or hydrocortisone acetate tablets may be prescribed to prevent adverse outcomes.
