Difference between 25-hydroxyvitamin D and vitamin D
Oct 12, 2022
Source: Cainiu Health
Dr. Wang Lei
Introduction
The differences between 25-hydroxyvitamin D and vitamin D are reflected in their distinct absorption mechanisms, bioavailability, and biological activity. 25-hydroxyvitamin D is primarily absorbed through the small intestine, whereas vitamin D needs to undergo a series of metabolic transformations in the liver to become 25-hydroxyvitamin D before it can be absorbed in the small intestine.
Under normal circumstances, the differences between 25-hydroxyvitamin D and vitamin D are reflected in their distinct absorption methods, bioavailability, and biological potency. Patients are advised to make appropriate choices under a doctor's guidance and avoid self-medication, which may negatively affect health. The specific details are as follows:
1. Different absorption pathways: 25-hydroxyvitamin D is primarily absorbed through the small intestine and then directly enters the bloodstream. In contrast, vitamin D must first undergo a series of metabolic transformations in the liver to become 25-hydroxyvitamin D before it can be absorbed by the small intestine.
2. Different bioavailability: The absorption of 25-hydroxyvitamin D is not affected by intestinal or liver damage, allowing it to enter the bloodstream directly after absorption, resulting in higher bioavailability. However, the absorption of vitamin D can be impaired by damage to the intestines or liver.
3. Different biological potency: 25-hydroxyvitamin D has a higher biological potency compared to vitamin D, with its potency being approximately 3 to 5 times greater than that of vitamin D.
