Can enteric-coated tablets be split and taken in half?
Nov 24, 2022
Source: Cainiu Health
Dr. Yang Shuwen
Introduction
Splitting an enteric-coated tablet and taking half a tablet results in both the outer and inner layers of the medication being digested and absorbed simultaneously, potentially leading to faster absorption compared to taking the whole tablet. Enteric-coated medications are designed to take effect gradually. Particularly for enteric-coated antidiabetic drugs, which typically exert their effects through intestinal digestion and absorption, splitting the tablet may cause part of the drug to be digested and absorbed already in the stomach.
Enteric-coated tablets should generally not be split into halves, as this may affect the drug's efficacy and irritate the gastric mucosa.
When an enteric-coated tablet is split in half, both the outer and inner layers of the medication are simultaneously digested and absorbed. The absorption rate may become faster compared to taking the whole tablet. However, enteric-coated drugs are designed to release gradually, especially hypoglycemic agents of this type, which typically exert their effects through digestion and absorption in the intestines. If split, part of the drug may already be digested and absorbed in the stomach, potentially compromising its therapeutic effect. Additionally, premature release in the stomach may irritate the gastric mucosa, leading to symptoms such as stomach pain and discomfort, thereby increasing patient distress.
Enteric-coated tablets must always be taken under a doctor's guidance; self-medication is not recommended. If a lower dosage is needed due to mild symptoms, a medication with a smaller dose should be used instead.
