Does long-term use of ademetionine enteric-coated tablets (adenosine disodium succinate) affect menstruation?

Nov 15, 2025 Source: Cainiu Health
Dr. Zhang Lu
Introduction
If the medication is taken regularly at the recommended dose under medical supervision for indications such as liver disease, and no adverse effects such as menstrual cycle disturbances or abnormal menstrual flow occur after use, it generally does not affect menstruation. The drug primarily acts on hepatic metabolism and has no clearly defined effects on the reproductive endocrine system; when used appropriately, it has minimal interference with menstrual regulatory mechanisms.

Under normal circumstances, regular use of ademetionine disulfate tosylate enteric-coated tablets typically does not affect the menstrual cycle if taken as prescribed and well tolerated by the individual. However, if the dosage is increased without medical guidance or if the person has a sensitive constitution, it may potentially impact menstruation. If there are any concerns, it is advisable to consult a healthcare provider in advance. Detailed analysis is as follows:

If the medication is taken regularly at the recommended dose under medical supervision for approved indications such as liver disease, and no menstrual disturbances (e.g., irregular cycles or abnormal flow) occur, it generally does not affect menstruation. This drug primarily acts on liver metabolism and has no clearly defined effects on the reproductive endocrine system; when used properly, its interference with menstrual regulatory mechanisms is minimal.

However, if the dosage is self-increased without following medical advice, or if the individual has an endocrine-sensitive constitution or a history of menstrual disorders, regular use of this medication may affect the menstrual cycle. Excessive dosing might indirectly disrupt metabolic balance, or the individual may be sensitive to the drug's components, potentially leading to prolonged menstrual cycles, reduced menstrual flow, or other issues. Any abnormal changes should be closely monitored.

When taking ademetionine disulfate tosylate enteric-coated tablets regularly, it is essential to strictly follow medical instructions and avoid adjusting the dosage independently. Menstrual patterns should be observed during treatment, and any abnormalities in cycle or flow should be promptly reported to a physician. Regular follow-up evaluations of health indicators are also recommended to ensure safe medication use and to prevent disruption of normal physiological cycles.

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