Is cervical intraepithelial neoplasia grade 1 (CIN1) serious?

Feb 07, 2023 Source: Cainiu Health

Dr. Lv Aiming

Introduction

Cervical intraepithelial neoplasia grade 1 (CIN1) is not serious. Strictly speaking, CIN1 is classified as a low-grade squamous intraepithelial lesion and does not fall under cervical precancerous conditions. Low-grade squamous intraepithelial lesions are usually manifestations of cervical inflammation or may result from HPV infection. Initial cervical cancer screening can be performed through HPV testing and TCT (liquid-based cytology).

Cervical intraepithelial neoplasia grade 1 (CIN1) is not serious.

Strictly speaking, cervical intraepithelial neoplasia grade 1 (CIN1) is classified as a low-grade squamous intraepithelial lesion and does not fall under cervical precancerous conditions. Low-grade squamous intraepithelial lesions may generally reflect cervical inflammation or be caused by HPV infection. Initial cervical cancer screening can be performed using HPV testing and TCT (thin-prep cytologic test). If results are abnormal, a cervical biopsy is required. Only the pathological findings from a cervical biopsy can definitively determine the presence of cervical precancerous lesions. In cases of cervical intraepithelial neoplasia grade 1 (CIN1), approximately 80% of individuals will experience spontaneous regression within one year; therefore, treatment is usually unnecessary and the condition often resolves on its own.

If follow-up examinations show that the cervix has returned to normal or that cervical intraepithelial neoplasia grade 1 (CIN1) remains unchanged, regular cervical monitoring should continue. However, if the lesion progresses to cervical intraepithelial neoplasia grade 2 (CIN2) or grade 3 (CIN3), surgical treatment with a cervical conization procedure is necessary to remove the abnormal cervical tissue. The excised tissue must undergo further pathological examination to confirm the diagnosis, based on which the next steps in treatment will be determined.

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