What is the probability of seroclearance with interferon treatment for "small three positives"?

Feb 23, 2023 Source: Cainiu Health

Dr. Jiang Weimin

Introduction

The probability of HBeAg-negative chronic hepatitis B patients achieving seroclearance with interferon treatment is approximately 19%, which is related to factors such as duration of infection, age, and individual immune function. If the infection duration is short and the patient has a relatively strong immune system, the likelihood of seroclearance is higher. Conversely, if the infection has been long-standing and the patient's immunity is weak, the chance of seroclearance is lower.

　　The chance of seroclearance in patients with "small three positive" hepatitis B is approximately 19%, and this probability is related to factors such as duration of infection, age, and the individual's immune function.

　　"Small three positive" refers to the presence of hepatitis B surface antigen (HBsAg), hepatitis B e antibody (HBeAb), and hepatitis B core antibody (HBcAb). Seroclearance in small three positive cases is difficult because after hepatitis B virus (HBV) infection, both HBeAb and HBcAb are produced and usually persist for life. Current medical treatments can only suppress the hepatitis B virus and reduce its infectivity, but cannot completely eliminate it. Clinically, when antiviral therapy with interferon leads to undetectable HBV DNA, it is considered that the "small three positive" status has achieved seroclearance. Clinical data show that under treatment with pegylated interferon, the HBV DNA negativity rate is about 19%, while the HBsAg seroclearance rate can reach up to 3%.

　　The likelihood of seroclearance in patients with "small three positive" hepatitis B depends on factors such as the patient's age and immune function. If the duration of infection is short and the patient has a strong immune system, the chance of seroclearance is higher. Conversely, if the infection has been long-standing and the patient's immunity is weak, the possibility of seroclearance is lower. Individuals with concerns about their condition should consult a qualified physician for professional advice.

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What Chinese herbs can completely cure "small three positives" (HBeAb, HBsAb, and HBcAb positive in hepatitis B)?

There is currently no traditional Chinese medicine that can completely cure "minor three positives" (a pattern of hepatitis B virus markers), but certain herbal medicines may help alleviate symptoms and regulate the immune system. Commonly used medications include Hugan Pian, Anluo Huaxian Wan, Yexiazhu Capsules, and Yinchenhao Tang. Hugan Pian contains ingredients such as Bupleurum and Artemisia capillaris (Yinchen), which help soothe the liver, regulate qi flow, and reduce transaminase levels. It is suitable for patients with "minor three positives" who have mild liver function abnormalities, and can improve symptoms such as distension and pain in the hypochondriac region and reduced appetite.