What is a urine culture and renal function panel of seven items?
Feb 26, 2023
Source: Cainiu Health
Dr. Yang Ziqi
Introduction
The seven-item sensitive kidney function urine test includes urinary albumin, urinary α1-microglobulin, urinary β2-microglobulin, urinary transferrin, urinary IgG, urinary NAG enzyme, and urinary retinol-binding protein. It is recommended not to drink excessive amounts of water before the sensitive kidney function test and to engage in moderate physical activity. If you catch a cold before the test, it is advised to wait until fully recovered before undergoing the test to ensure the accuracy of the results.
Renal function sensitivity panel of seven tests includes urinary albumin, urinary α1-microglobulin, urinary β2-microglobulin, urinary transferrin, urinary IgG, urinary NAG enzyme, and urinary retinol-binding protein.
1. Urinary Albumin
Urinary microalbumin is an early sensitive indicator for predicting diabetes, hypertension, cardiovascular diseases, and vascular injury. Currently, there is great emphasis on measuring urinary microalbumin, as this parameter is considered highly significant for early treatment of primary diseases, monitoring disease progression, and assessing related risk factors.
2. Urinary α1-Microglobulin
Urinary α1-microglobulin is a glycoprotein with a normal reference range of 0–12 mg/L. It is an important clinical indicator for evaluating kidney function and is primarily used in the diagnosis, differential diagnosis, and monitoring of kidney diseases.
3. Urinary β2-Microglobulin
Measurement of urinary β2-microglobulin is a sensitive and specific diagnostic method that has significance in detecting early renal damage. The normal value of β2-microglobulin ranges from 0 to 0.2 mg/L.
4. Urinary Transferrin
The main physiological function of urinary transferrin is iron transport. It belongs to acute-phase reactant proteins and is one of the indicators of early glomerular injury, primarily reflecting damage to the charge-selective barrier of the glomerular filtration membrane.
5. Urinary IgG
Urinary IgG is commonly used in selective urine protein indices. This involves measuring two proteins with significantly different molecular weights in both serum and urine of patients, including urinary IgG.
6. Urinary NAG Enzyme
Urinary N-acetyl-β-D-glucosaminidase (NAG) is an intracellular lysosomal enzyme found in highest concentration in the proximal renal tubules. It is one of the sensitive clinical markers for kidney injury.
7. Urinary Retinol-Binding Protein
Urinary retinol-binding protein is a transport protein for vitamin A in blood and is essential for human health. Measuring this marker can help assess overall health status. It exists in body fluids such as blood, cerebrospinal fluid, and urine, and is mainly synthesized by the liver. Its normal range is 0.5–140 μg/mL. Levels within the normal range generally indicate good health without liver or kidney diseases, and suggest adequate supply of relevant nutrients including vitamins.
It is recommended not to drink excessive amounts of water before undergoing the renal function sensitivity test, and to engage in moderate physical activity. If a cold or infection occurs prior to testing, it is advisable to wait until fully recovered before taking the test to ensure accurate results.
