Cervical CIN grading
Mar 27, 2023
Source: Cainiu Health
Dr. Lv Aiming
Introduction
Cervical CIN generally refers to cervical intraepithelial neoplasia. Cervical CIN is graded into three levels: grade 1, grade 2, and grade 3. It is primarily used to indicate precancerous stages of dysplastic changes in squamous epithelium, corresponding to the depth of abnormal cells invading the epithelium covering the cervix. Cervical CIN grade 1 indicates the presence of a low-grade squamous intraepithelial lesion in the cervical region.
Cervical CIN generally refers to cervical intraepithelial neoplasia. Cervical CIN is classified into three grades: grade 1, grade 2, and grade 3. It is primarily used to describe precancerous stages of squamous epithelial dysplasia, with the grading related to the depth to which abnormal cells have penetrated the epithelial layer covering the cervix.
Cervical CIN grade 1 indicates a low-grade squamous intraepithelial lesion, in which abnormal cell growth involves up to one-third of the thickness of the epithelial lining covering the cervix. Patients with this condition who receive timely standardized treatment have a relatively low risk of progressing to malignant cancer.
2. Cervical CIN grade 2
This represents a high-grade squamous intraepithelial lesion. At this stage, abnormal cells are present in between one-third and two-thirds of the epithelial thickness covering the cervix. CIN2 is defined by nuclear pleomorphism and mitotic activity extending into the upper two-thirds of the epithelium. The risk of progression to invasive cancer is increased at this stage.
3. Cervical CIN grade 3
This is categorized as a high-grade squamous intraepithelial lesion or carcinoma in situ. It is characterized by abnormal cells involving the full thickness of the cervical epithelium. Patients require prompt surgical intervention and other treatments to remove or destroy the abnormal cervical cells as early as possible.
This type of lesion is usually closely associated with HPV (human papillomavirus) infection of the cervix. Patients who receive a diagnosis should seek medical evaluation promptly and undergo standardized treatment under medical guidance to reduce the future risk of malignant transformation.
