What medications should not be used with clindamycin?
Mar 29, 2023
Source: Cainiu Health
Dr. Yang Shuwen
Introduction
Clindamycin is a broad-spectrum antibiotic, and its concurrent use with certain medications may lead to adverse reactions or affect drug efficacy. Medications that should not be used together with clindamycin include cefradine tablets, warfarin sodium tablets, aluminum-containing preparations, etc. In addition, clindamycin should not be used concomitantly with fentanyl citrate injection. During treatment with clindamycin, patients should follow medical instructions.
Generally, clindamycin is a broad-spectrum antibiotic. Drugs that should not usually be used concurrently include cefradine tablets, warfarin sodium tablets, aluminum-containing preparations, etc. The specific analysis is as follows:
1. Cefradine Tablets
Concurrent use with cefradine tablets may interfere with each other's efficacy. Alcohol should be avoided during medication.
2. Warfarin Sodium Tablets
Clindamycin can disrupt intestinal microbiota, reduce vitamin K synthesis, and thereby increase the plasma concentration of warfarin sodium, enhancing its anticoagulant effect. Therefore, these two drugs should not be used together.
3. Botulinum Toxin Type A
Clindamycin hydrochloride tablets may enhance the effects of neuromuscular blocking agents. Since botulinum toxin type A is a neuromuscular blocker that relaxes muscles, it should not be used simultaneously with clindamycin.
In addition, clindamycin should not be used concomitantly with fentanyl citrate injection. During clindamycin treatment, patients should follow medical advice and avoid co-administration with the above-mentioned drugs to prevent adverse reactions or reduced drug efficacy. If concurrent use of other medications is necessary, it should be done under the guidance of a physician.
