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High uric acid, elevated alanine aminotransferase

May 16, 2023 Source: Cainiu Health
Dr. Liu Aihua
Introduction
Elevated uric acid and alanine aminotransferase levels may stem from conditions such as gout, nephritis, and viral hepatitis. Gout leads to abnormal uric acid metabolism and kidney damage, resulting in the release of alanine aminotransferase. Nephritis causes uric acid retention and increased production of inflammatory mediators, which promote enzyme synthesis. Viral hepatitis damages liver cells, leading to the release of uric acid and alanine aminotransferase.

Under normal circumstances, elevated uric acid and increased alanine aminotransferase (ALT) levels may be caused by gout, nephritis, viral hepatitis, or other conditions. Targeted treatments are available. Specific analyses are as follows:

1. Gout

High-purine diets and excessive alcohol consumption increase the risk of gout, leading to abnormal uric acid metabolism and consequently elevated uric acid levels. Gout can also damage the kidneys, causing renal dysfunction. Impaired kidney function may result in tissue and cellular damage throughout the body, releasing enzymes such as alanine aminotransferase and increasing their blood levels. Patients can take medications such as benzbromarone tablets, colchicine tablets, allopurinol tablets, and Qingpeng ointment under medical guidance.

2. Nephritis

Nephritis may occur when the kidneys are infected by viruses or bacteria. It impairs the kidney's filtration and excretion functions, preventing timely elimination of uric acid from the body and resulting in elevated uric acid levels. The body may also produce large amounts of inflammatory mediators such as interleukins, which enhance the liver’s ability to synthesize alanine aminotransferase, thereby increasing ALT levels in the blood. Patients can follow medical advice to use medications such as furosemide injection, erythromycin tablets, and methylprednisolone tablets.

3. Viral Hepatitis

Infection with hepatitis viruses such as hepatitis A or hepatitis B virus can lead to viral hepatitis. The inflammatory response causes damage and death of liver cells, releasing biochemical markers including uric acid and alanine aminotransferase into the bloodstream, thus increasing their levels. Patients can receive treatment under medical supervision using drugs such as azathioprine tablets, bicyclol tablets, and recombinant human interferon α2b injection.

In addition to the above, elevated uric acid and ALT levels may also be caused by hyperuricemia or fatty liver disease. Comprehensive analysis and diagnosis based on clinical symptoms and examination results are required. If abnormalities occur, prompt medical consultation and treatment are necessary.


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