Do B cells have MHC molecules on their surface?
May 30, 2023
Source: Cainiu Health
Dr. Zhang Heyang
Introduction
B cells generally refer to B lymphocytes. Under normal circumstances, B lymphocytes express MHC molecules on their surface. MHC molecules are major histocompatibility complexes. Surface molecules on B lymphocytes mainly include leukocyte differentiation antigens, major histocompatibility complexes, and various membrane receptors. Major histocompatibility complexes are found on the surface of almost all nucleated cells.
B cells generally refer to B lymphocytes. Under normal circumstances, MHC molecules are present on the surface of B lymphocytes. The specific details are as follows:
MHC molecules, or major histocompatibility complex molecules, are found on the surface of B lymphocytes along with other surface molecules such as leukocyte differentiation antigens and various membrane receptors. The major histocompatibility complex is expressed on almost all nucleated cells, although expression levels vary significantly among different tissue cells. MHC can be divided into classical and non-classical types. Classical MHC includes MHC class I, MHC class II, and MHC class III genes, which encode MHC class I, MHC class II, and MHC class III molecules, respectively.
MHC class I molecules are located on the surface of most cells and provide information about the internal status of these cells. MHC class II molecules are primarily found on antigen-presenting cells, such as macrophages. MHC class III genes mainly encode components of the complement system, tumor necrosis factor, heat shock proteins, and 21-hydroxylase.
It should be noted that if abnormalities in the structure or number of B lymphocytes occur, leading to discomfort or symptoms, prompt medical attention is recommended.
