What does it mean if HBDH is elevated, and what should be done?
Jun 05, 2023
Source: Cainiu Health
Dr. Yang Ziqi
Introduction
HBDH usually refers to α-hydroxybutyrate dehydrogenase, an enzyme in the cardiac enzyme panel. Elevated levels may be caused by factors such as the neonatal period, heavy alcohol consumption, intense physical exercise, viral myocarditis, or myocardial infarction. It is recommended to seek medical attention promptly, identify the underlying cause, and receive symptomatic treatment under the guidance of a qualified physician. Drinking adequate water can help promote the elimination of alcohol metabolites.
HBDH usually refers to α-hydroxybutyrate dehydrogenase, an enzyme in the cardiac enzyme panel. Elevated levels may be caused by factors such as the neonatal period, excessive alcohol consumption, intense physical exercise, viral myocarditis, or myocardial infarction. It is recommended to seek medical attention promptly, identify the underlying cause, and receive symptomatic treatment under the guidance of a qualified physician.
1. Neonatal Period
During the neonatal period, all organs and tissues are still developing. The amount of α-hydroxybutyrate dehydrogenase released from cells into the bloodstream may be higher than in adults, which is a normal physiological phenomenon. As the newborn's body gradually matures, this condition typically resolves naturally. No special treatment is required; close monitoring of the newborn’s health is sufficient.
2. Excessive Alcohol Consumption
Alcohol is primarily metabolized in the liver. Excessive drinking can damage liver cells. When liver cells are injured, intracellular enzymes—including α-hydroxybutyrate dehydrogenase—are released into the bloodstream, leading to elevated levels. It is important to quit or reduce alcohol intake. Drinking more water may help promote the elimination of alcohol metabolites.
3. Intense Physical Exercise
During intense exercise, muscles undergo significant anaerobic respiration, increasing intracellular metabolic byproducts and causing elevated α-hydroxybutyrate dehydrogenase levels. Adequate rest is recommended to allow the body to recover. Levels typically return to normal after a period of rest as metabolism stabilizes.
4. Viral Myocarditis
When viruses infect the heart muscle, they trigger an inflammatory response in myocardial cells. This inflammation damages the cells, causing α-hydroxybutyrate dehydrogenase to be released into the bloodstream and resulting in elevated levels. Patients may experience symptoms such as fever, palpitations, fatigue, and arrhythmias. It is recommended to take medications such as coenzyme Q10 capsules, ribavirin granules, and vitamin C tablets under a doctor's supervision to relieve symptoms.
5. Myocardial Infarction
Myocardial infarction occurs when coronary arteries become blocked, leading to ischemia and necrosis of heart muscle cells. This causes a large release of α-hydroxybutyrate dehydrogenase from damaged myocardial cells into the blood, significantly increasing its concentration. Patients may also experience chest pain, chest tightness, and shortness of breath. Medications such as aspirin tablets, nitroglycerin tablets, and atorvastatin calcium tablets may be used as directed by a physician to alleviate symptoms.
In daily life, maintain a light diet and avoid spicy or irritating foods such as garlic, hot pot, and mustard. Ensure adequate rest and avoid overexertion to protect overall health.
