What are the pathogenesis and pathological process of psoriasis?

Aug 01, 2023 Source: Cainiu Health

Dr. Liu Wan

Introduction

Research has shown that many psoriasis patients have a family history, indicating a strong relationship between the disease and genetic factors. Clinical studies indicate that the HLA-Cw6 gene is particularly important in psoriasis, and changes in the HLA-Cw6 gene are closely associated with the development of this condition. Under normal circumstances, the human immune system can recognize and eliminate pathogens.

The pathogenesis of psoriasis has not yet been fully elucidated, but research indicates that it is closely associated with genetic factors and immune system abnormalities. The main pathological processes involve abnormal cell proliferation and inflammatory responses.

1. Pathogenesis

1.1 Genetic Factors

Studies have found that many psoriasis patients have a family history, indicating a strong genetic component. Clinical research shows that the HLA-Cw6 gene plays a significant role in psoriasis, and variations in this gene are closely linked to the development of the disease.

1.2 Immune System Abnormalities

Under normal conditions, the human immune system can recognize and eliminate pathogens. However, in psoriasis patients, the immune system mounts an abnormal response against normal tissues, which contributes to the development of the disease.

2. Pathological Process

In general, the differentiation and shedding process of keratinocytes in psoriasis patients differs from that in healthy individuals. Patients exhibit a faster rate of cell proliferation compared to the general population, leading to the characteristic symptoms of psoriasis.

Patients with related conditions are advised to seek active treatment under medical supervision. Additionally, proper skin care should be maintained in daily life to prevent recurrent infections.

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