Is hepatitis B DNA 300 IU/mL normal?

In general, hepatitis B refers to the hepatitis B virus (HBV). An HBV DNA level of 300 IU/mL is considered abnormal and elevated. Elevated HBV DNA levels may be associated with factors such as low immunity, immune tolerance phase, hepatitis B recurrence, alcoholic hepatitis, liver cancer, and others. Patients are advised to follow medical guidance for symptomatic treatment. Specific analyses are as follows:

1. Low Immunity

If patients do not pay attention to prevention in daily life, smoke or drink excessively, or have poor lifestyle habits, their immune system may become weakened, potentially leading to increased HBV DNA levels. This is a common situation that can usually be alleviated by adjusting lifestyle habits, including quitting smoking and abstaining from alcohol.

2. Immune Tolerance Phase

The immune tolerance phase refers to the early stage of HBV infection, during which the patient's immune system does not mount an effective response against the virus, allowing HBV to replicate extensively within the body, thereby increasing HBV DNA levels. Under medical supervision, patients may use medications such as entecavir tablets or tenofovir alafenamide fumarate tablets for treatment.

3. Hepatitis B Recurrence

When resistance decreases due to overexertion, excessive physical activity, exposure to cold, or other causes, the immune regulatory system may malfunction, allowing HBV to proliferate and resulting in elevated quantitative HBV DNA levels. Under medical guidance, patients may use medications such as Shugan Yipi Granules or Hugan Tablets for treatment.

4. Alcoholic Hepatitis

If long-term or excessive alcohol consumption leads to high quantitative HBV DNA levels, it indicates that the patient’s drinking habit has caused liver damage and resulted in alcoholic hepatitis. Common symptoms include fatigue, loss of appetite, and nausea. After diagnosis, patients must stop drinking alcohol and receive liver-protective treatment with medications such as compound glycyrrhizin tablets or silybin capsules.

5. Liver Cancer

Liver cancer refers to malignant tumors in the liver, typically caused by chronic HBV infection, improper diet, genetic factors, and others. Due to the presence of cancer cells in the liver, patients may show elevated HBV DNA levels during testing. Under medical supervision, patients may use medications such as lenvatinib mesylate capsules or regorafenib tablets. When necessary, combination therapies such as chemotherapy, radiotherapy, or surgery may also be used.

If patients experience any discomfort, they are advised to seek timely medical evaluation at a hospital to avoid delays in diagnosis and treatment.