What is the most common ototoxic drug?
Jan 24, 2024
Source: Cainiu Health
Dr. Lu Cheng
Introduction
Ototoxic drugs refer to medications that may negatively affect the structure or function of the ear, leading to hearing damage or other auditory problems. There is no single drug considered the "most common" ototoxic agent. Generally, commonly encountered ototoxic drugs include kanamycin sulfate capsules, enteric-coated erythromycin tablets, enteric-coated aspirin tablets, quinine sulfate tablets, and vincristine sulfate for injection.
Ototoxic drugs refer to medications that may negatively affect the structure or function of the ear, leading to hearing damage or other auditory problems. There is no definitive answer to "which drug is the most commonly ototoxic." Generally, frequently encountered ototoxic drugs include kanamycin sulfate capsules, enteric-coated erythromycin tablets, enteric-coated aspirin tablets, quinine sulfate tablets, and vinblastine sulfate for injection. If necessary, individuals should seek medical evaluation and use these medications strictly as directed by a healthcare provider. Detailed analysis is as follows:
1. Kanamycin Sulfate Capsules
Kanamycin sulfate capsules are an aminoglycoside antibiotic that may damage the vestibulocochlear nerve, causing tinnitus, dizziness, balance disorders, and even potentially leading to deafness.
2. Enteric-Coated Erythromycin Tablets
Enteric-coated erythromycin tablets are an antibiotic; high doses of erythromycin may negatively affect the auditory nerve, possibly resulting in tinnitus, hearing loss, or deafness.
3. Enteric-Coated Aspirin Tablets
Enteric-coated aspirin inhibits prostaglandin production, which may cause blood vessel spasms and insufficient blood supply in the inner ear. When used at high doses, it may lead to tinnitus, hearing loss, or deafness.
4. Quinine Sulfate Tablets
Quinine sulfate tablets are an antimalarial medication. Prolonged use may result in symptoms such as tinnitus, headache, nausea, and hearing impairment. In severe cases, temporary deafness may occur, although hearing typically returns to normal after discontinuation of the drug.
5. Vinblastine Sulfate for Injection
Vinblastine sulfate for injection is an antitumor agent that may have direct toxic effects on hair cells or nerves within the ear, potentially causing hearing damage.
Medications should be used appropriately according to a physician's instructions to avoid adverse reactions caused by improper self-administration.
