What deficiency causes Keshan disease?
Sep 06, 2024
Source: Cainiu Health
Dr. Tian Hongbo
Introduction
Keshan disease usually occurs in Keshan County of Heilongjiang Province, China, and its surrounding areas. The disease may be caused by a combination of factors including genetics, geographical environment, malnutrition, viral infections, and immune dysfunction. It is important to adjust dietary habits and, under medical guidance, take selenium supplements such as selenium yeast tablets or selenium-enriched wheat germ tablets to increase selenium levels in the body.
Generally, Keshan disease is a type of endemic cardiomyopathy closely associated with selenium deficiency. It may be caused by a combination of factors including genetics, geographical environment, malnutrition, viral infections, and immune dysfunction. If any discomfort occurs, prompt medical attention is recommended. A detailed analysis is as follows:
1. Genetic Factors
Genetics may influence the metabolism, structure, and function of myocardial cells, thereby affecting individual sensitivity and responsiveness to selenium or vitamin E. For cases of Keshan disease linked to genetic factors, gene testing and genetic counseling may be necessary to determine an individual's specific requirements and responses to selenium or vitamin E.
2. Geographical Environment
High-incidence areas of Keshan disease are typically located in regions with low selenium levels. The soil, water sources, and food in these areas contain insufficient selenium. It is advisable to consume selenium-rich foods such as seafood, meat, nuts, and whole grains.
3. Malnutrition
Chronic malnutrition can lead to weakened immunity and impaired myocardial cell metabolism, increasing the risk of developing Keshan disease. Symptoms may include weight loss, anemia, and edema. Adequate intake of protein, fats, and carbohydrates should be ensured, along with supplementation of essential vitamins and minerals.
4. Viral Infections
Infection with Coxsackievirus group B can damage myocardial cells and trigger Keshan disease. Systemic symptoms of viral infection such as fever and fatigue may also occur. Antiviral medications such as ribavirin tablets, acyclovir tablets, or amoxicillin capsules should be used under medical supervision.
5. Immune Dysfunction
Selenium deficiency can impair normal immune system function, leading to excessive inflammatory responses that damage myocardial tissue and contribute to the development of Keshan disease. Symptoms may include skin redness and swelling. Under medical guidance, immunomodulatory drugs such as cyclosporine soft capsules, methotrexate tablets, or pidotimod oral solution may be prescribed for treatment.
In daily life, adjusting dietary habits is important. Selenium supplements such as selenium yeast tablets or selenium-enriched malt tablets may be taken under medical supervision to increase selenium levels in the body.
